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<?xml version="1.0" encoding="UTF-8"?>

<channelml xmlns="http://morphml.org/channelml/schema"
    xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"
    xmlns:meta="http://morphml.org/metadata/schema"
    xsi:schemaLocation="http://morphml.org/channelml/schema  http://www.neuroml.org/NeuroMLValidator/NeuroMLFiles/Schemata/v1.8.1/Level2/ChannelML_v1.8.1.xsd"
    units="Physiological Units"
>


    
<meta:notes>ChannelML file containing a single Channel description</meta:notes>

    
<channel_type name="NaChannel" density="yes">
        
        
<status value="stable">
            
<meta:comment>Equations adapted from HH paper for modern convention of external potential being zero</meta:comment>
            
<meta:contributor>
                
<meta:name>Padraig Gleeson</meta:name>
            
</meta:contributor>
        
</status>

        
<meta:notes>Simple example of Na conductance in squid giant axon. Based on channel from Hodgkin and Huxley 1952</meta:notes>
        
        
<meta:authorList>
            
<meta:modelTranslator>
                
<meta:name>Padraig Gleeson</meta:name>
                
<meta:institution>UCL</meta:institution>    
                
<meta:email>p.gleeson - at - ucl.ac.uk</meta:email>
            
</meta:modelTranslator>
        
</meta:authorList>

        
<meta:publication>
            
<meta:fullTitle>A. L. Hodgkin and A. F. Huxley, A quantitative description of membrane current and
            its application to conduction and excitation in nerve, J. Physiol., vol. 117, pp. 500-544, 1952.
</meta:fullTitle>
            
<meta:pubmedRef>http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=pubmed&amp;dopt=Abstract&amp;list_uids=12991237</meta:pubmedRef>
        
</meta:publication>

        
<meta:neuronDBref>
            
<meta:modelName>Na channels</meta:modelName>
            
<meta:uri>http://senselab.med.yale.edu/senselab/NeuronDB/channelGene2.htm#table2</meta:uri>
        
</meta:neuronDBref>
        
        
<current_voltage_relation cond_law="ohmic" ion="na" default_erev="50" default_gmax="120">
            
            
<gate name="m" instances="3">
                
<closed_state id="m0"/>
                
<open_state   id="m"/>

                
<transition name="alpha" from="m0" to="m" expr_form="exp_linear"  
                            rate="1" scale="10"  midpoint="-40"/
>
  
                
<transition name="beta"  from="m" to="m0" expr_form="exponential"
                            rate="4" scale="-18" midpoint="-65"/
>
  
            
</gate>
            
            
<gate name="h" instances="1">
                
<closed_state id="h0"/>
                
<open_state   id="h"/>

                
<transition name="alpha" from="h0" to="h" expr_form="exponential"
                            rate="0.07" scale="-20" midpoint="-65"/
>
  
                
<transition name="beta"  from="h" to="h0" expr_form="sigmoid"    
                            rate="1" scale="-10" midpoint="-35"/
>
    
            
</gate>
            
        
</current_voltage_relation>
        
        
    
</channel_type>
</channelml>