Transforming XML file: NeuroMLFiles/Examples/ChannelML/KChan_KineticScheme.xml using XSL file: NeuroMLFiles/Schemata/v1.8.1/Level3/NeuroML_Level3_v1.8.1

Transforming XML file: NeuroMLFiles/Examples/ChannelML/KChan_KineticScheme.xml using XSL file: NeuroMLFiles/Schemata/v1.8.1/Level3/NeuroML_Level3_v1.8.1_HTML.xsl

View original file before transform

Converting the file: KChan_KineticScheme.xml

General notes

Notes present in ChannelML file

Example of 5 state kinetic scheme K conductance specified in ChannelML.

Unit system of ChannelML file

This can be either SI Units or Physiological Units (milliseconds, centimeters, millivolts, etc.)

Physiological Units

Channel: KChannelKS

Name KChannelKS

Description

As described in the ChannelML file

K conductance with 5 kinetic states. NOTE: currently a mapping is only provided to the NEURON Channel Builder format and PSICS

Current voltage relationship ohmic

Ion involved in channel

The ion which is actually flowing through the channel and its default reversal potential. Note that the reversal potential will normally depend on the internal and external concentrations of the ion at the segment on which the channel is placed.

k (default E_k = -77.0 mV)

Default maximum conductance density

Note that the conductance density of the channel will be set when it is placed on the cell.

G_max = 36 mS cm^-2

Conductance expression

Expression giving the actual conductance as a function of time and voltage

G_k(v,t) = G_max * n(v,t)

Current due to channel

Ionic current through the channel

I_k(v,t) = G_k(v,t) * (v - E_k)

Gate: n

The equations below determine the dynamics of gating state n

Instances of gating elements 1

Closed state n0

Closed state n1

Closed state n2

Closed state n3

Open state n   (fractional conductance: 1)

    Transition: alpha_n0_n1 from n0 to n1

Expression alpha_n0_n1(v) = A*((v-V_1/2)/B) / (1 - exp(-(v-V_1/2)/B))    (exp_linear)

Parameter values A = 0.4 ms^-1   B = 10 mV   V_1/2 = -55 mV

Substituted

alpha_n0_n1(v) = 0.4 * ( v - (-55)) / 10
1- e^{-((
v - (-55)) / 10)}

    Transition: beta_n0_n1 from n1 to n0

Expression beta_n0_n1(v) = A*exp((v-V_1/2)/B)    (exponential)

Parameter values A = 0.125 ms^-1   B = -80 mV   V_1/2 = -65 mV

Substituted beta_n0_n1(v) = 0.125 * e ^{(v - (-65))/-80}

    Transition: alpha_n1_n2 from n1 to n2

Expression alpha_n1_n2(v) = A*((v-V_1/2)/B) / (1 - exp(-(v-V_1/2)/B))    (exp_linear)

Parameter values A = 0.3 ms^-1   B = 10 mV   V_1/2 = -55 mV

Substituted

alpha_n1_n2(v) = 0.3 * ( v - (-55)) / 10
1- e^{-((
v - (-55)) / 10)}

    Transition: beta_n1_n2 from n2 to n1

Expression beta_n1_n2(v) = A*exp((v-V_1/2)/B)    (exponential)

Parameter values A = 0.25 ms^-1   B = -80 mV   V_1/2 = -65 mV

Substituted beta_n1_n2(v) = 0.25 * e ^{(v - (-65))/-80}

    Transition: alpha_n2_n3 from n2 to n3

Expression alpha_n2_n3(v) = A*((v-V_1/2)/B) / (1 - exp(-(v-V_1/2)/B))    (exp_linear)

Parameter values A = 0.2 ms^-1   B = 10 mV   V_1/2 = -55 mV

Substituted

alpha_n2_n3(v) = 0.2 * ( v - (-55)) / 10
1- e^{-((
v - (-55)) / 10)}

    Transition: beta_n2_n3 from n3 to n2

Expression beta_n2_n3(v) = A*exp((v-V_1/2)/B)    (exponential)

Parameter values A = 0.375 ms^-1   B = -80 mV   V_1/2 = -65 mV

Substituted beta_n2_n3(v) = 0.375 * e ^{(v - (-65))/-80}

    Transition: alpha_n3_n from n3 to n

Expression alpha_n3_n(v) = A*((v-V_1/2)/B) / (1 - exp(-(v-V_1/2)/B))    (exp_linear)

Parameter values A = 0.1 ms^-1   B = 10 mV   V_1/2 = -55 mV

Substituted

alpha_n3_n(v) = 0.1 * ( v - (-55)) / 10
1- e^{-((
v - (-55)) / 10)}

    Transition: beta_n3_n from n to n3

Expression beta_n3_n(v) = A*exp((v-V_1/2)/B)    (exponential)

Parameter values A = 0.5 ms^-1   B = -80 mV   V_1/2 = -65 mV

Substituted beta_n3_n(v) = 0.5 * e ^{(v - (-65))/-80}

Time to transform file: 0.165 secs